University of California San Francisco

Biography

Valerie M. Weaver, Ph.D., is the Director of the Center for Bioengineering and Tissue Regeneration in the Department of Surgery. She earned her Bachelor of Science degree at the University of Waterloo in Biochemistry/Chemistry in 1985, continuing her education for an Honors Bachelor of Science in Biochemistry at the University of Ottawa (graduating Summa cum Laude). Dr. Weaver earned her doctorate degree, Ph.D, from the University of Ottawa in Biochemistry in 1992.

After receiving her doctorate, Dr. Weaver was awarded the Molecular Cell Biology and Apoptosis Research Group and the Institute for Biological Sciences of Canada Postdoctoral Fellow from 1992-1994.  From 1994-1998, she was distinguished as the Postdoctoral Fellow at the Lawrence Berkeley National Laboratory at the University of California, Berkeley, in the Cancer and Cell Biology Group, Life Sciences Division.

Following her fellowships, Dr. Weaver has held principle positions within academia. Prior to her appointment at UCSF, she was an Adjunct Associate Professor with the Department of Bioengineering at the University of Pennsylvania from 1999 to 2006. In her current position, she is an Professor with the Department of Surgery at the Universality of California, San Francisco.

Additionally, Dr. Weaver is the Director for the Center for Bioengineering & Tissue Regeneration with the Department of Surgery and UCSF, an Associate Professor in the Department of Anatomy at UCSF, and Adjunct Associate Professor for the department of Bioengineering at UPenn. From 1999 to 2006 she was a member at the Institute for Medicine and Engineering at UPenn.

Dr. Weaver's extensive honors and awards include: the Breast Cancer Scholar Award with the Department of Defense, the International Society of Differentiation Young Investigator Travel Award, the Alberta Heritable Foundation for Medical Research Lecturer Award, and the University of California Breast Cancer Research Program Postdoctoral Grant.

She also proudly serves on the Editorial Board for Cancer Biology & Therapy, was a guest editor in 2004 for J. Mammary Gland Biology and Neoplasia, and is currently an Ad Hoc Reviewer for several distinguished journals, including: Cancer Research, American Journal of Cell Biology, European Journal of Cell Biology, Molecular Carcinogenesis, Journal of the National Cancer Institute, Oncogene, FASEB Journal, Journal of Cell Science, Laboratory Investigation, Cancer Letters, Breast Cancer Research, Journal of Biological Chemistry, Molecular Biology of the Cell, Molecular and Cellular Biology, & Clinical Cancer Research. 

Education

Institution Degree Dept or School End Date
University of California Diversity, Equity, and Inclusion Champion Training 04/2021

Program Affiliations

Helen Diller Family Comprehensive Cancer Center

Biomedical Sciences Graduate Program

Developmental Stem Cell Biology Graduate Program

Grants and Funding

  • Tissue mechanics reprograms the tissue to malignancy and metastasis | NIH | 2020-09-01 - 2027-08-31 | Role: Principal Investigator
  • A physical sciences approach to investigate the role of exosomes in metastatic progression | NIH | 2021-09-16 - 2026-08-31 | Role: Co-Principal Investigator
  • Targeting the Cancer Glycocalyx | NIH | 2019-03-01 - 2024-02-29 | Role: Co-Principal Investigator
  • Reorienting the Glioblastoma Microenvironment to Respond to Immunotherapy | NIH | 2019-02-01 - 2024-01-31 | Role: Co-Principal Investigator
  • Tissue Tension, RANK and Breast Cancer Risk | NIH | 2018-02-09 - 2023-01-31 | Role: Principal Investigator
  • ECM geometrical and mechanical properties modulate RTK signaling | NIH | 2015-09-22 - 2021-08-31 | Role: Co-Principal Investigator
  • Tension-Stat3-miR-mediated metastasis | NIH | 2015-04-01 - 2021-03-31 | Role: Principal Investigator
  • Inside-Out Approaches to Improve Wound Repair by HoxB3 | NIH | 2016-07-15 - 2020-04-30 | Role: Principal Investigator
  • A biophysical stromal basis for radiation sensitivity in ductal carcinoma in situ | NIH | 2014-05-05 - 2020-02-29 | Role: Co-Principal Investigator
  • Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor M | NIH | 2014-05-02 - 2018-04-30 | Role: Co-Principal Investigator
  • TGF-beta Suppression and Promotion of Mammary Carcinomas | NIH | 2000-05-20 - 2017-02-28 | Role: Co-Principal Investigator
  • Biophysical and molecular dialogue of glioma cells and the brain microenvironment | NIH | 2011-09-26 - 2016-07-31 | Role: Co-Principal Investigator
  • 2015 Fibronectin, Integrins & Related Molecules Gordon Research Conference & Gordon Research Seminar | NIH | 2015-05-01 - 2016-04-30 | Role: Principal Investigator
  • Collagen remodeling and tumor progression | NIH | 2010-05-07 - 2016-02-29 | Role: Principal Investigator
  • Role of Fibroblasts, Myeloid Cells and Matrix in PDAC | NIH | 2010-09-30 - 2015-08-31 | Role: Co-Principal Investigator
  • Fundamental Mechanobiology of Tumor Progression | NIH | 2009-09-29 - 2015-07-31 | Role: Co-Investigator
  • 2013 Fibronectin, Integrins & Related Molecules GRC/GRS | NIH | 2013-02-06 - 2014-01-31 | Role: Principal Investigator
  • NFkB, tissue polarity and apoptosis resistance | NIH | 2000-07-01 - 2010-06-30 | Role: Principal Investigator

Research Narrative

Dr. Weaver has over 20 years of experience in leading interdisciplinary research in oncology, including leadership of significant program projects merging approaches in the physical/engineering sciences and biology.  Her research focuses on the contribution of force, cell-intrinsic as well as extracellular matrix, to oncogenesis and tumor development. Her group employs 2- and 3-D in vitro cell culture techniques, clinical samples and animal models with force application techniques, and traction force and atomic force microscopy to assess the influence of the mechanical aspects of the cell environment on cell behavior and tumor progression. Dr. Weaver has been awarded many distinctions for her work demonstrating the critical importance of tissue structure in the treatment response of tumors, including the prestigious Department of Defense Era of Hope Breast Cancer Scholar Award for her innovative interdisciplinary research efforts on the effect of mechanical force on breast cancer progression and treatment response. Along with Dr. Jan Liphardt, PhD, UC Berkeley, she was awarded the prestigious Physical Sciences and Oncology Center Grant, whose aim is to integrate physical sciences approaches toward better understanding tumor biology. The Center encompasses close to 100 investigators in physics, engineering, mathematics, chemistry, cell and molecular biology, and clinical sciences from UC Berkeley, UCSF, and LBNL. In addition, Dr. Weaver a Co-PI on an NIH U01 grant with Dr. Werb on environmental stressors in mammary gland development and a Co-PI with Drs. Kalluri and Moses on role of fibroblasts, myeloid cells and matrix in PDAC.

Dr. Weaver is the TMEN-BCC co-PI with Dr. Bergers, as well as the leader of Project 3,in which she is testing the hypothesis that the mechanoproperties of SVZ-derived GBM, together with elevated cranial pressure and ECM stiffness, promote GBM aggressiveness and recurrence, in part by affecting the vascular and tumor stem cell compartment.

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 190
  1. Forcing the code: tension modulates signaling to drive morphogenesis and malignancy.
    Narain R, Muncie-Vasic JM, Weaver VM| | PubMed
  2. Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option.
    Uroz M, Stoddard AE, Sutherland BP, Courbot O, Oria R, Li L, Ravasio CR, Ngo MT, Yang J, Tefft JB, Eyckmans J, Han X, Elosegui-Artola A, Weaver VM, Chen CS| | PubMed
  3. Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling.
    Nakagawa R, Beardsley A, Durney S, Hayward MK, Subramanyam V, Meyer NP, Wismer H, Goodarzi H, Weaver VM, Van de Mark D, Goga A| | PubMed
  4. nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
    Hendley AM, Ashe S, Urano A, Ng M, Phu TA, Peng XL, Luan C, Finger AM, Jang GH, Kerper NR, Berrios DI, Jin D, Lee J, Riahi IR, Gbenedio OM, Chung C, Roose JP, Yeh JJ, Gallinger S, Biankin AV, O'Kane GM, Ntranos V, Chang DK, Dawson DW, Kim GE, Weaver VM, Raffai RL, Hebrok M| | PubMed
  5. Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
    Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, Combes AJ, Weaver VM| | PubMed
  6. Patterning and folding of intestinal villi by active mesenchymal dewetting.
    Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ| | PubMed
  7. Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore.
    Fiore A, Yu G, Northey JJ, Patel R, Ravenscroft TA, Ikegami R, Kolkman W, Kumar P, Grimm JB, Dilan TL, Ruetten VMS, Ahrens MB, Shroff H, Lavis LD, Wang S, Weaver VM, Pedram K| | PubMed
  8. Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    Goyette MA, Stevens LE, DePinho CR, Seehawer M, Nishida J, Li Z, Wilde CM, Li R, Qiu X, Pyke AL, Zhao S, Lim K, Tender GS, Northey JJ, Riley NM, Long HW, Bertozzi CR, Weaver VM, Polyak K| | PubMed
  9. Asymmetric crowders and membrane morphology at the nexus of intracellular trafficking and oncology.
    Parihar K, Ko SB, Bradley RP, Taylor P, Ramakrishnan N, Baumgart T, Guo W, Weaver VM, Janmey PA, Radhakrishnan R| | PubMed
  10. Free energy calculations for membrane morphological transformations and insights to physical biology and oncology.
    Parihar K, Ko SH, Bradley R, Taylor P, Ramakrishnan N, Baumgart T, Guo W, Weaver VM, Janmey PA, Radhakrishnan R| | PubMed
  11. Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry.
    Darula Z, McCabe MC, Barrett A, Schmitt LR, Maslanka MD, Saviola AJ, Orgel J, Burlingame A, Staab-Weijnitz CA, Stenmark K, Weaver V, Chalkley RJ, Hansen KC| | PubMed
  12. Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.
    Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF| | PubMed
  13. Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.
    Northey JJ, Hayward MK, Yui Y, Stashko C, Kai F, Mouw JK, Thakar D, Lakins JN, Ironside AJ, Samson S, Mukhtar RA, Hwang ES, Weaver VM| | PubMed
  14. The microenvironment dictates glycocalyx construction and immune surveillance.
    Tharp KM, Park S, Timblin GA, Richards AL, Berg JA, Twells NM, Riley NM, Peltan EL, Shon DJ, Stevenson E, Tsui K, Palomba F, Lefebvre AEYT, Soens RW, Ayad NME, Hoeve-Scott JT, Healy K, Digman M, Dillin A, Bertozzi CR, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, Weaver VM| | PubMed
  15. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
    Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR| | PubMed
  16. Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.
    Ayad NME, Lakins JN, Ghagre A, Ehrlicher AJ, Weaver VM| | PubMed
  17. A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.
    Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM| | PubMed
  18. Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.
    Kersten K, You R, Liang S, Tharp KM, Pollack J, Weaver VM, Krummel MF, Headley MB| | PubMed
  19. Stiff matrix induces exosome secretion to promote tumour growth.
    Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W| | PubMed
  20. Programming the Self-Organization of Endothelial Cells into Perfusable Microvasculature.
    Cabral KA, Srivastava V, Graham AJ, Coyle MC, Stashko C, Weaver V, Gartner ZJ| | PubMed
  21. Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression.
    Northey JJ, Weaver VM| | PubMed
  22. Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality.
    Gaietta G, Kai F, Swift MF, Weaver VM, Volkmann N, Hanein D| | PubMed
  23. Mechanosensitive Steroid Hormone Signaling and Cell Fate.
    Northey JJ, Weaver VM| | PubMed
  24. Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.
    Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival JLP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, Lakins JN, Vahdat L, Weaver VM, Smolka MB, Span PN, Lammerding J| | PubMed
  25. ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
    Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM| | PubMed
  26. Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.
    Tsai KK, Huang SS, Northey JJ, Liao WY, Hsu CC, Cheng LH, Werner ME, Chuu CP, Chatterjee C, Lakins JN, Weaver VM| | PubMed
  27. Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.
    Metcalf KJ, Hayward MK, Berens E, Ironside AJ, Stashko C, Hwang ES, Weaver VM| | PubMed
  28. NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
    Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA| | PubMed
  29. Mechanobiology: forcing the second act.
    Weaver VM| | PubMed
  30. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.
    Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J| | PubMed
  31. Tissue mechanics in stem cell fate, development, and cancer.
    Hayward MK, Muncie JM, Weaver VM| | PubMed
  32. EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.
    Kindberg AA, Srivastava V, Muncie JM, Weaver VM, Gartner ZJ, Bush JO| | PubMed
  33. Adhesion-mediated mechanosignaling forces mitohormesis.
    Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM| | PubMed
  34. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
    Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M| | PubMed
  35. Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.
    Drain AP, Zahir N, Northey JJ, Zhang H, Huang PJ, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen YY, Park CC, Weaver VM| | PubMed
  36. Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.
    Hayward MK, Weaver VM| | PubMed
  37. Leveraging microenvironmental synthetic lethalities to treat cancer.
    Metcalf KJ, Alazzeh A, Werb Z, Weaver VM| | PubMed
  38. Membrane Tension Locks In Pluripotency.
    Muncie JM, Weaver VM| | PubMed
  39. Derivation of a nuclear heterogeneity image index to grade DCIS.
    Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC, Shelley Hwang E, Weaver VM| | PubMed
  40. Proteoglycans as Mediators of Cancer Tissue Mechanics.
    Barkovskaya A, Buffone A, Žídek M, Weaver VM| | PubMed
  41. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
    Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM| | PubMed
  42. Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.
    Muncie JM, Ayad NME, Lakins JN, Xue X, Fu J, Weaver VM| | PubMed
  43. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
    Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, Hansen KC, Littlepage LE, Weaver VM| | PubMed
  44. Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon.
    Weaver VM, Bissell MJ| | PubMed
  45. In Memoriam - Zena Werb 1945-2020.
    Barcellos-Hoff MH, Weaver VM| | PubMed
  46. Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.
    Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, Stashko C, Volmar K, Yeh JJ, Weaver VM, Wang ZJ, Tempero MA, Weichert W, Collisson EA| | PubMed
  47. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
    Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY| | PubMed
  48. Zena Werb 1945-2020.
    Egeblad M, Coussens LM, Weaver VM| | PubMed
  49. Fibrosis and cancer: A strained relationship.
    Piersma B, Hayward MK, Weaver VM| | PubMed
  50. Tension in tumour cells keeps metabolism high.
    Ayad NME, Weaver VM| | PubMed
  51. A framework for advancing our understanding of cancer-associated fibroblasts.
    Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z| | PubMed
  52. Don't sugarcoat it: How glycocalyx composition influences cancer progression.
    Buffone A, Weaver VM| | PubMed
  53. Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.
    Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM| | PubMed
  54. Controlled modelling of human epiblast and amnion development using stem cells.
    Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J| | PubMed
  55. Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.
    Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS| | PubMed
  56. Tissue mechanics, an important regulator of development and disease.
    Ayad NME, Kaushik S, Weaver VM| | PubMed
  57. The Extracellular Matrix Modulates the Metastatic Journey.
    Kai F, Drain AP, Weaver VM| | PubMed
  58. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.
    Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC| | PubMed
  59. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.
    Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM| | PubMed
  60. Modeling Tissue Polarity in Context.
    Tharp KM, Weaver VM| | PubMed
  61. Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.
    Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M| | PubMed
  62. Compartment resolved proteomics reveals a dynamic matrisome in a biomechanically driven model of pancreatic ductal adenocarcinoma.
    Barrett AS, Maller O, Pickup MW, Weaver VM, Hansen KC| | PubMed
  63. The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.
    Muncie JM, Weaver VM| | PubMed
  64. New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.
    Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM| | PubMed
  65. Feeling Stress: The Mechanics of Cancer Progression and Aggression.
    Northcott JM, Dean IS, Mouw JK, Weaver VM| | PubMed
  66. Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.
    Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI| | PubMed
  67. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.
    Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z| | PubMed
  68. Excess area dependent scaling behavior of nano-sized membrane tethers.
    Ramakrishnan N, Sreeja KK, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Patil S, Weaver VM, Radhakrishnan R| | PubMed
  69. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.
    Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR| | PubMed
  70. Tissue Force Programs Cell Fate and Tumor Aggression.
    Northey JJ, Przybyla L, Weaver VM| | PubMed
  71. α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.
    Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Hannachi EI, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM| | PubMed
  72. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.
    Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV| | PubMed
  73. Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.
    Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vázquez-Naharro A, Santamaria PG, Morales S, Dubus PR, Muinelo-Romay L, López-López R, Tung JC, Weaver VM, Portillo F, Cano A| | PubMed
  74. Cell and tissue mechanics: the new cell biology frontier.
    Weaver VM| | PubMed
  75. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.
    Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF| | PubMed
  76. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.
    Oudin MJ, Weaver VM| | PubMed
  77. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.
    Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF| | PubMed
  78. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.
    Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM| | PubMed
  79. Tissue mechanics regulate brain development, homeostasis and disease.
    Barnes JM, Przybyla L, Weaver VM| | PubMed
  80. Force-dependent breaching of the basement membrane.
    Chang TT, Thakar D, Weaver VM| | PubMed
  81. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.
    Takai K, Le A, Weaver VM, Werb Z| | PubMed
  82. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer.
    Kaushik S, Pickup MW, Weaver VM| | PubMed
  83. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.
    Chan TS, Hsu CC, Pai VC, Liao WY, Huang SS, Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jiang KY, Chu JM, Lien GS, Weaver VM, Tsai KK| | PubMed
  84. Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.
    Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM| | PubMed
  85. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease.
    Gilbert PM, Weaver VM| | PubMed
  86. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.
    Przybyla L, Lakins JN, Weaver VM| | PubMed
  87. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions.
    Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM| | PubMed
  88. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer.
    Przybyla L, Muncie JM, Weaver VM| | PubMed
  89. Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes.
    Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S| | PubMed
  90. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
    Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM| | PubMed
  91. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
    Kai F, Laklai H, Weaver VM| | PubMed
  92. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.
    Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L| | PubMed
  93. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.
    Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT| | PubMed
  94. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
    Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R| | PubMed
  95. Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells.
    Ou G, Weaver VM| | PubMed
  96. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.
    Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA| | PubMed
  97. Monitoring developmental force distributions in reconstituted embryonic epithelia.
    Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM| | PubMed
  98. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.
    Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI| | PubMed
  99. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.
    Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM| | PubMed
  100. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.
    Northcott JM, Northey JJ, Barnes JM, Weaver VM| | PubMed
  101. Tumor mechanics and metabolic dysfunction.
    Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM| | PubMed
  102. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.
    Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM| | PubMed
  103. The extracellular matrix modulates the hallmarks of cancer.
    Pickup MW, Mouw JK, Weaver VM| | PubMed
  104. Extracellular matrix assembly: a multiscale deconstruction.
    Mouw JK, Ou G, Weaver VM| | PubMed
  105. The microenvironment matters.
    Weaver VM| | PubMed
  106. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.
    Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM| | PubMed
  107. Multicellular architecture of malignant breast epithelia influences mechanics.
    Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH| | PubMed
  108. The cancer glycocalyx mechanically primes integrin-mediated growth and survival.
    Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM| | PubMed
  109. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.
    Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R| | PubMed
  110. Understanding tissue context influences on intratumour heterogeneity.
    Michor F, Weaver VM| | PubMed
  111. Deconstructing signaling in three dimensions.
    Rubashkin MG, Ou G, Weaver VM| | PubMed
  112. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.
    Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM| | PubMed
  113. Rapid disorganization of mechanically interacting systems of mammary acini.
    Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT| | PubMed
  114. Cell biology. Strength under tension.
    Bainer R, Weaver V| | PubMed
  115. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.
    Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL| | PubMed
  116. Collagen architecture in pregnancy-induced protection from breast cancer.
    Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P| | PubMed
  117. Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.
    Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM| | PubMed
  118. YAP forces fibroblasts to feel the tension.
    Maller O, DuFort CC, Weaver VM| | PubMed
  119. MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.
    Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ| | PubMed
  120. A physical sciences network characterization of non-tumorigenic and metastatic cells.
    Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH| | PubMed
  121. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.
    Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK| | PubMed
  122. Scanning angle interference microscopy reveals cell dynamics at the nanoscale.
    Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM| | PubMed
  123. Morphogenesis: Laying down the tracks.
    Cassereau L, DuFort CC, Weaver VM| | PubMed
  124. The extracellular matrix: a dynamic niche in cancer progression.
    Lu P, Weaver VM, Werb Z| | PubMed
  125. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.
    Lakins JN, Chin AR, Weaver VM| | PubMed
  126. Extracellular matrix degradation and remodeling in development and disease.
    Lu P, Takai K, Weaver VM, Werb Z| | PubMed
  127. In situ force mapping of mammary gland transformation.
    Lopez JI, Kang I, You WK, McDonald DM, Weaver VM| | PubMed
  128. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
    Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF| | PubMed
  129. Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick.
    Weaver V| | PubMed
  130. Balancing forces: architectural control of mechanotransduction.
    DuFort CC, Paszek MJ, Weaver VM| | PubMed
  131. Tumor microenvironment and progression.
    Dvorak HF, Weaver VM, Tlsty TD, Bergers G| | PubMed
  132. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties.
    Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver VM| | PubMed
  133. The extracellular matrix at a glance.
    Frantz C, Stewart KM, Weaver VM| | PubMed
  134. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis.
    Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY| | PubMed
  135. Forcing form and function: biomechanical regulation of tumor evolution.
    Yu H, Mouw JK, Weaver VM| | PubMed
  136. Dynamic interplay between the collagen scaffold and tumor evolution.
    Egeblad M, Rasch MG, Weaver VM| | PubMed
  137. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
    Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA| | PubMed
  138. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
    Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM| | PubMed
  139. Biophysics. Enforcing order on signaling.
    Paszek M, Weaver V| | PubMed
  140. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.
    Paszek MJ, Boettiger D, Weaver VM, Hammer DA| | PubMed
  141. Matrix crosslinking forces tumor progression by enhancing integrin signaling.
    Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM| | PubMed
  142. Mechanics, malignancy, and metastasis: the force journey of a tumor cell.
    Kumar S, Weaver VM| | PubMed
  143. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.
    Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ| | PubMed
  144. The tissue diagnostic instrument.
    Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J| | PubMed
  145. Multiscale modeling of form and function.
    Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM| | PubMed
  146. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
    Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL| | PubMed
  147. A tense situation: forcing tumour progression.
    Butcher DT, Alliston T, Weaver VM| | PubMed
  148. Biomechanical regulation of cell orientation and fate.
    Lopez JI, Mouw JK, Weaver VM| | PubMed
  149. Three-dimensional context regulation of metastasis.
    Erler JT, Weaver VM| | PubMed
  150. A human breast cell model of preinvasive to invasive transition.
    Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell MJ| | PubMed
  151. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.
    Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK| | PubMed
  152. Integrin-mediated signalling through the MAP-kinase pathway.
    Yee KL, Weaver VM, Hammer DA| | PubMed
  153. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures.
    Hebner C, Weaver VM, Debnath J| | PubMed
  154. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.
    Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM| | PubMed
  155. G'rab'bing the microenvironment for invasion.
    Weaver V, Werb Z| | PubMed
  156. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis.
    Kass L, Erler JT, Dembo M, Weaver VM| | PubMed
  157. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis.
    Johnson KR, Leight JL, Weaver VM| | PubMed
  158. The ultrastructure of MCF-10A acini.
    Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA| | PubMed
  159. Forcing the third dimension.
    Boudreau N, Weaver V| | PubMed
  160. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard.
    Yan Y, Weaver VM, Blair IA| | PubMed
  161. Tensional homeostasis and the malignant phenotype.
    Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM| | PubMed
  162. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.
    Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG| | PubMed
  163. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression.
    Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC| | PubMed
  164. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.
    Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA| | PubMed
  165. The tension mounts: mechanics meets morphogenesis and malignancy.
    Paszek MJ, Weaver VM| | PubMed
  166. Watch thy neighbor: cancer is a communal affair.
    Weaver VM, Gilbert P| | PubMed
  167. Death in the third dimension: apoptosis regulation and tissue architecture.
    Zahir N, Weaver VM| | PubMed
  168. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.
    Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM| | PubMed
  169. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.
    Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP| | PubMed
  170. The tissue microenvironment as an epigenetic tumor modifier.
    Unger M, Weaver VM| | PubMed
  171. The organizing principle: microenvironmental influences in the normal and malignant breast.
    Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW| | PubMed
  172. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.
    Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ| | PubMed
  173. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?
    Weaver VM| | PubMed
  174. Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.
    Chrenek MA, Wong P, Weaver VM| | PubMed
  175. Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods.
    Weaver VM, Buckley T, Groopman JD| | PubMed
  176. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture.
    Spancake KM, Anderson CB, Weaver VM, Matsunami N, Bissell MJ, White RL| | PubMed
  177. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3.
    Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R| | PubMed
  178. Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells.
    Weaver VM, Bissell MJ| | PubMed
  179. Tissue structure, nuclear organization, and gene expression in normal and malignant breast.
    Bissell MJ, Weaver VM, Lelièvre SA, Wang F, Petersen OW, Schmeichel KL| | PubMed
  180. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.
    Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ| | PubMed
  181. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus.
    Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ| | PubMed
  182. Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.
    Schmeichel KL, Weaver VM, Bissell MJ| | PubMed
  183. Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.
    Petersen OW, Rønnov-Jessen L, Weaver VM, Bissell MJ| | PubMed
  184. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.
    Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ| | PubMed
  185. Extracellular matrix: the central regulator of cell and tissue homeostasis.
    Weaver VM, Roskelley CD| | PubMed
  186. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.
    Weaver VM, Carson CE, Walker PR, Chaly N, Lach B, Raymond Y, Brown DL, Sikorska M| | PubMed
  187. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation.
    Lelièvre S, Weaver VM, Bissell MJ| | PubMed
  188. The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay.
    Weaver VM, Fischer AH, Peterson OW, Bissell MJ| | PubMed
  189. The development of a functionally relevant cell culture model of progressive human breast cancer.
    Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ| | PubMed
  190. Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes.
    Weaver VM, Lach B, Walker PR, Sikorska M| | PubMed