Biography
Dr. Roy is a professor at the University of California, San Francisco in the Department of Bioengineering and Therapeutic Sciences (BTS), a joint department of the UCSF Schools of Pharmacy and Medicine, and is a faculty affiliate of the California Institute for Quantitative Biosciences (QB3). He is the director of the Biodesign Laboratory located on the Mission Bay campus. In addition, he serves as the Technical Director of The Kidney Project and is a founding member of the UCSF Pediatric Device Consortium. Dr. Roy is the Faculty Director of the joint UCSF-UC Berkeley Master of Translational Medicine (MTM) program. He has developed and currently teaches a course focused on medical device development and commercialization issues. He is the author of more than 100 publications and co-author of five book chapters, and holds multiple patents for device developments.
Before joining UCSF in 2008, Dr. Roy co-directed the BioMEMS Laboratory in the Department of Biomedical Engineering at Cleveland Clinic in Cleveland, Ohio, focusing on clinical applications of MEMS. In 1992 he earned a BS degree, magna cum laude, for triple majors in physics, mathematics, and computer science, from Mount Union College in Alliance, Ohio. In 1995, he earned an MS in electrical engineering and applied physics and, in 2001, he earned a PhD in electrical engineering and computer science, both from Case Western Reserve University in Cleveland, Ohio.
He is the recipient of a Top 40 under 40 award by Crain’s Cleveland Business in 1999 and the Clinical Translation Award at the 2nd Annual BioMEMS and Biomedical Nanotechnology World 2001 meeting. In 2003, Dr. Roy was selected as a recipient of the TR100, which features the world’s 100 Top Young Innovators as selected by Technology Review, the Massachusetts Institute of Technology’s Magazine of Innovation. In 2004, he was presented with a NASA Group Achievement Award for his work on harsh environment MEMS. In 2005, Dr. Roy was named as a Who’s Who in Biotechnology by Crain’s Cleveland Business. In 2005 and 2007, he was recognized as a Cleveland Clinic Innovator. In 2009, he was nominated for the Biotechnology Industry Organization's Biotech Humanitarian Award, which is given in recognition of an individual who has used biotechnology to unlock its potential to improve the earth. In 2012, he was presented the Rising Star Award by BayBio Pantheon, and in that same year, he received the Innovation Pathway 2.0 Award from the Food and Drug Administration (FDA). More recently, he was recognized as a Fellow by the American Institute of Medical and Biological Engineering (AIMBE). He is the recipient of the KidneyX Redesign Dialysis Phase 1 Prize, KidneyX Redesign Dialysis Phase 2 Prize, the KidneyX Artificial Kidney Phase 1 Prize, and most recently, the KidneyX Artificial Kidney Phase 2 Prize.
Videos
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Medal of Excellence - Breakthrough Innovations | American Association of Kidney Patients | 2022 |
Presidential Volunteer Service Award - Gold Medal | U.S. Presidential Volunteer Service awards - nomination by American Association of Kidney Patients | 2022 |
Commendation for Exceptional Volunteerism and University Service | Organized, Rapid, Intelligent Fabrication (ORIF) Team for UCSF's COVD-19 Pandemic Response | 2021 |
KidneyX Artificial Kidney Phase 1, Winner | US Dept. of Health and Human Services & American Society of Nephrology | 2021 |
KidneyX Redesign Dialysis Phase 2, Winner | US Dept. of Health and Human Services & American Society of Nephrology | 2020 |
Dean's Apple Award - Outstanding Efforts and Commitment to Pharmacy Education | UCSF PharmD Degree Program | 2019 |
KidneyX Redesign Dialysis Phase 1, Winner | US Dept. of Health and Human Services & American Society of Nephrology | 2019 |
Elected Fellow of American Institute of Medical and Biological Engineering (AIMBE) | American Institute of Medical and Biological Engineering (AIMBE) | 2017 |
La Renon TANKER foundation For the Sake of Honour Award | Tamilnad Kidney Research Foundation (TANKER) | 2017 |
Annual Home Dialyzors United (HDU) Chris Blagg Award | Home Dialyzors United (HDU) | 2016 |
Innovation in Regulatory Science, Finalist | Burroughs Wellcome Fund | 2015 |
UCSF Outstanding Faculty Mentorship Award, Finalist | UCSF | 2014 |
Fellow | Applied Innovation Institute | 2013 |
Requested Nominator | Heinz Awards | 2013 |
Rising Star Award | BayBio Pantheon | 2012 |
Innovation Pathway 2.0 Award | Food and Drug Administration (FDA) | 2012 |
UCSF Outstanding Faculty Mentorship Award, Finalist | University of California, San Francisco | 2012 |
mHealth Alliance Award | Vodafone Americas Foundation | 2011 |
Images of the Year Selection | Biomaterials Journal | 2009 |
Biotech Humanitarian Award Finalist | Biotechnology Industry Organization | 2009 |
Thomas G. Orr Memorial Lectureship | Southwestern Surgical Congress | 2008 |
Cleveland Clinic Innovator Award | Cleveland Clinic | 2007 |
Mentor Recognition Award | Cleveland Clinic Science Internship Program | 2006 |
Cleveland Clinic Innovator Award | Cleveland Clinic | 2005 |
Who's Who in Biotechnology | Crain's Cleveland Business | 2005 |
Ribbon Award, Outstanding Symposium Paper, MRS Fall Meeting | Materials Research Society | 2004 |
NASA Group Achievement Award, Harsh Environment MEMS | NASA | 2004 |
MIT TR100 Award, Top 100 Young Innovators | Technology Review Magazine | 2003 |
Clinical Translation Award | BioMEMS and Biomedical Nanotechnology World Meeting | 2001 |
Top 40 Under 40 | Crain's Cleveland Business | 1999 |
Ruth Barber Moon Graduate Student Award | Case Western Reserve University | 1998 |
Senior Physics Prize | Mount Union College | 1992 |
William and Burdella Carl Mathematics Award | Mount Union College | 1989 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Case Western Reserve University | PhD | Electrical Engineering and Computer Science | 2001 |
Case Western Reserve University | MS | Electrical Engineering and Applied Physics | 1995 |
Mount Union College | BS | Physics, Mathematics, Computer Science | 1992 |
Program Affiliations
UCSF - UC Berkeley Joint Graduate Group in Bioengineering
Pharmaceutical Sciences and Pharmacogenomics Graduate Program (PSPG)
UC Berkeley - UCSF Master of Translational Medicine (MTM) Program California Institute for Quantitative Biosciences (QB3)
In the News
Grants and Funding
- Biodevice Innovation Training Program | NIH | 2017-05-15 - 2022-04-30 | Role: Co-Principal Investigator
- Implantable Bio-Artificial Pancreas (iBAP) | NIH | 2017-09-26 - 2021-06-30 | Role: Principal Investigator
- Building an Implantable Artificial Kidney | NIH | 2015-09-30 - 2021-06-30 | Role: Principal Investigator
- Biocompatibility of Implantable Renal Replacement Devices | NIH | 2012-05-01 - 2017-04-30 | Role: Principal Investigator
- Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy | NIH | 2007-09-30 - 2011-08-31 | Role: Principal Investigator
- Microneedle Array for Catheter Drug Delivery | NIH | 2003-09-12 - 2006-08-31 | Role: Principal Investigator
Research Narrative
Chronic kidney failure threatens about half a million people in the U.S. alone. Donated kidneys can restore health, but they are in are in short supply. As a result, some 350,000 people with failing kidneys are tethered to dialysis machines several days a week – a tiring, uncomfortable and expensive treatment, and one that falls far short of performing a normal kidney’s functions. Shuvo Roy, a professor in the UCSF Department of Bioengineering and Therapeutic Sciences, and his colleagues are developing an implantable, fully functional artificial kidney.
Research projects include:
- Development of an artificial kidney
- Development of an intravascular bioreactor for islet therapy in Type 1 diabetes patients
- Investigation into covalent attachment of self-assembled monolayer films to enhance biocompatibility of implanted devices
- Resorbable electronics for tissue monitoring and stimulation, and dataloggers for patient monitoring
- Development of compact hemofilters for renal replacement therapy
- Wireless sensing systems for load measurement
- Focused ultrasound transducers for minimally invasive imaging and therapy
Research Interests
Therapeutics
Bioengineering
Medical Devices
Microelectromechanical Systems
BioMEMS
Sensors
Transducers
Biocompatibility
Artificial Organs
Microtextured Substrates
Renal Replacement
Tissue Engineering
Nanotechnology
Artificial Kidney
Publications
- An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs.| | PubMed
- Patient Preference Trade-offs for Next-Generation Kidney Replacement Therapies.| | PubMed
- Renal Embolization-Induced Uremic Swine Model for Assessment of Next-Generation Implantable Hemodialyzers.| | PubMed
- Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.| | PubMed
- Characterization of human islet function in a convection-driven intravascular bioartificial pancreas.| | PubMed
- Silicon membranes for extracorporeal life support: a comparison of design and fabrication methodologies.| | PubMed
- Inhibition of Transforming Growth Factor-β Improves Primary Renal Tubule Cell Differentiation in Long-Term Culture.| | PubMed
- Functionalizing Polyacrylamide Hydrogels for Renal Cell Culture Under Fluid Shear Stress.| | PubMed
- Wearable and implantable artificial kidney devices for end-stage kidney disease treatment: Current status and review.| | PubMed
- The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo.| | PubMed
- Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications.| | PubMed
- Opportunities for Regulatory Changes to Promote Pediatric Device Innovation in the United States: Joint Recommendations From Pediatric Innovator Roundtables.| | PubMed
- Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia.| | PubMed
- Advances in extracorporeal membrane oxygenator design for artificial placenta technology.| | PubMed
- Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells.| | PubMed
- Treating the kidneys - a new era in the United States (and beyond).| | PubMed
- Ambulatory Hemodialysis-Technology Landscape and Potential for Patient-Centered Treatment.| | PubMed
- Endovascular Ion Exchange Chemofiltration Device Reduces Off-Target Doxorubicin Exposure in a Hepatic Intra-arterial Chemotherapy Model.| | PubMed
- Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function.| | PubMed
- Ultrafiltration for management of fluid overload in patients with heart failure.| | PubMed
- Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.| | PubMed
- In Vitro models for thrombogenicity testing of blood-recirculating medical devices.| | PubMed
- Application of physiological shear stress to renal tubular epithelial cells.| | PubMed
- Compliance monitoring via a Bluetooth-enabled retainer: A prospective clinical pilot study.| | PubMed
- Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.| | PubMed
- In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants.| | PubMed
- Orbital Shear Stress Regulates Differentiation and Barrier Function of Primary Renal Tubular Epithelial Cells.| | PubMed
- Acoustic Methods for Pulmonary Diagnosis.| | PubMed
- Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO).| | PubMed
- Innovations in Wearable and Implantable Artificial Kidneys.| | PubMed
- Improved Detection of Lung Fluid With Standardized Acoustic Stimulation of the Chest.| | PubMed
- Tabla: A Proof-of-Concept Auscultatory Percussion Device for Low-Cost Pneumonia Detection.| | PubMed
- Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.| | PubMed
- Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo.| | PubMed
- Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.| | PubMed
- Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients.| | PubMed
- Slit pores preferred over cylindrical pores for high selectivity in biomolecular filtration.| | PubMed
- Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices.| | PubMed
- Silicon Micropore-Based Parallel Plate Membrane Oxygenator.| | PubMed
- Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | PubMed
- An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | PubMed
- A distributed solute model: an extended two-pore model with application to the glomerular sieving of Ficoll.| | PubMed
- Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models.| | PubMed
- Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.| | PubMed
- Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation.| | PubMed
- A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.| | PubMed
- Quantifying and Reducing Motion Artifacts in Wearable Seismocardiogram Measurements During Walking to Assess Left Ventricular Health.| | PubMed
- Inductive passive sensor for intraparenchymal and intraventricular monitoring of intracranial pressure.| | PubMed
- Diffusive Silicon Nanopore Membranes for Hemodialysis Applications.| | PubMed
- First Implantation of Silicon Nanopore Membrane Hemofilters.| | PubMed
- Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.| | PubMed
- Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.| | PubMed
- Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices.| | PubMed
- MyPectus: First-in-human pilot study of remote compliance monitoring of teens using dynamic compression bracing to correct pectus carinatum.| | PubMed
- Corrigendum to: Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.| | PubMed
- A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables.| | PubMed
- Impedance sensing device enables early detection of pressure ulcers in vivo.| | PubMed
- The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells.| | PubMed
- Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.| | PubMed
- Current strategies and challenges in engineering a bioartificial kidney.| | PubMed
- Impedance sensing device for monitoring ulcer healing in human patients.| | PubMed
- Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography.| | PubMed
- Rapid and low-cost prototyping of medical devices using 3D printed molds for liquid injection molding.| | PubMed
- Imaging assessment of a portable hemodialysis device: detection of possible failure modes and monitoring of functional performance.| | PubMed
- Miniaturizing RFID for magnamosis.| | PubMed
- Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features.| | PubMed
- Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces.| | PubMed
- Microelectromechanical systems and nephrology: the next frontier in renal replacement technology.| | PubMed
- A low-frequency versatile wireless power transfer technology for biomedical implants.| | PubMed
- Towards BirthAlert--A Clinical Device Intended for Early Preterm Birth Detection.| | PubMed
- Response of bone marrow derived connective tissue progenitor cell morphology and proliferation on geometrically modulated microtextured substrates.| | PubMed
- The bioartificial kidney: current status and future promise.| | PubMed
- Achieving more frequent and longer dialysis for the majority: wearable dialysis and implantable artificial kidney devices.| | PubMed
- Fabric-based pressure sensor array for decubitus ulcer monitoring.| | PubMed
- Novel device to trend impedance and fluorescence of the cervix for preterm birth detection.| | PubMed
- Implantable ultra-low pulmonary pressure monitoring system for fetal surgery.| | PubMed
- A feed-forward controlled AC-DC boost converter for biomedical implants.| | PubMed
- Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia.| | PubMed
- Hemocompatibility of silicon-based substrates for biomedical implant applications.| | PubMed
- Anti-biofouling Sulfobetaine Polymer Thin Films on Silicon and Silicon Nanopore Membranes.| | PubMed
- The Responsivity of a Miniaturized Passive Implantable Wireless Pressure Sensor.| | PubMed
- A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells.| | PubMed
- Basal lamina secreted by MDCK cells has size- and charge-selective properties.| | PubMed
- Design and analysis of MEMS based PVDF ultrasonic transducers for vascular imaging.| | PubMed
- Molecular conformation and filtration properties of anionic Ficoll.| | PubMed
- Silicon induces minimal thromboinflammatory response during 28-day intravascular implant testing.| | PubMed
- Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers.| | PubMed
- Characterizing the surface charge of synthetic nanomembranes by the streaming potential method.| | PubMed
- Permeability - Selectivity Analysis for Ultrafiltration: Effect of Pore Geometry.| | PubMed
- A high-power versatile wireless power transfer for biomedical implants.| | PubMed
- The implantable artificial kidney.| | PubMed
- Modulating human connective tissue progenitor cell behavior on cellulose acetate scaffolds by surface microtextures.| | PubMed
- Solute partitioning and filtration by extracellular matrices.| | PubMed
- Post microtextures accelerate cell proliferation and osteogenesis.| | PubMed
- A three-dimensional scaffold with precise micro-architecture and surface micro-textures.| | PubMed
- Biomolecular transport through hemofiltration membranes.| | PubMed
- High-Performance Silicon Nanopore Hemofiltration Membranes.| | PubMed
- Development of multistage magnetic deposition microscopy.| | PubMed
- Basic Science Symposium II: MEMS Technology.| | PubMed
- In Vivo Assessment of Bone Graft/Endplate Contact Pressure in a Caprine Interbody Pseudarthrosis Model: A Preliminary Biomechanical Characterization of the Fusion Process for the Development of a Microelectromechanical Systems (MEMS) Biosensor.| | PubMed
- A preliminary biomechanical evaluation in a simulated spinal fusion model. Laboratory investigation.| | PubMed
- Quantification of magnetic susceptibility in several strains of Bacillus spores: implications for separation and detection.| | PubMed
- Ficoll is not a rigid sphere.| | PubMed
- Development of continuous implantable renal replacement: past and future.| | PubMed
- Connective tissue progenitor cell growth characteristics on textured substrates.| | PubMed
- Differentiated growth of human renal tubule cells on thin-film and nanostructured materials.| | PubMed
- Electrochemical detection and characterization of proteins.| | PubMed
- Continuous flow magnetic cell fractionation based on antigen expression level.| | PubMed
- Orthogonal-coil RF probe for implantable passive sensors.| | PubMed
- Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells.| | PubMed
- Spine biomechanics: fundamentals and future.| | PubMed
- Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems.| | PubMed
- A system for micro/nano fluidic flow diagnostics.| | PubMed
- Micromachines in spine surgery.| | PubMed
- Osteoblast attachment to a textured surface in the absence of exogenous adhesion proteins.| | PubMed
- Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces.| | PubMed
- Analysis of connective tissue progenitor cell behavior on polydimethylsiloxane smooth and channel micro-textures.| | PubMed
- Evaluation of MEMS materials of construction for implantable medical devices.| | PubMed
- Biomaterials and implantable devices: discoveries in the spine surgery arena.| | PubMed