University of California San Francisco

David M. Young, MD

Dr. David Young large headshot
David
Young
MD

Professor of Surgery
Division of Plastic and Reconstructive Surgery

Address

513 Parnassus Avenue, MSB, #549A
San Francisco, CA 94143
United States

Email: [email protected]
Phone: 415-206-8814
Fax: 628-206-5484

Biography

Dr. David Young is Professor of Plastic Surgery at UCSF. His area of expertise includes wound healing, microsurgery, and reconstruction after burns and trauma. His research interests include the molecular mechanisms of wound healing and the epidemiology and treatment of soft tissue infections.

Dr. Young is a graduate of Columbia College and earned a medical degree at the Yale University School of Medicine. He trained in pathology at Cornell Medical College and general surgery at the University of Miami/Jackson Memorial Hospital.  He then completed an NIH-NRSA funded research Fellowship at Yale and a Plastic Surgery Fellowship at the University of California, San Francisco.

Education

Institution Degree Dept or School End Date
University of California, San Francisco Residency

Board Certifications

  • American Board of Surgery, 1992
  • American Board of Plastic Surgery, 1996

Clinical Expertise

Abdominoplasty
Acute Trauma Hand Surgery
Reconstructive Hand Surgery
Aesthetic Surgery
Breast Lift
Breast Reconstruction
Breast Reduction
Breast Augentation
Facial Rejuvenation
Hand and Microvascular Surgery
Liposuction
Microsurgery
Microvascular Reconstruction
Burns and Trauma Reconstruction
Skin Cancer Reconstruction
Wound healing

Clinical Trials

  1. Placebo Controlled Study of Antibiotic Treatment of Soft Tissue Infection (NCT00187759)
    Related Conditions: Soft Tissue Infections| Start Date:

In the News

Innovative Research by Dr. David M. Young Featured in The Chronicle of Higher Education
January, 26, 2016 | UCSF Surgical Innovations Program
Department of Surgery Research Teams Awarded Seed Funding at Inaugural Shark Tank Event
October, 23, 2015 | UCSF Surgical Innovations Program
‘Smart Bandage’ Detects Bedsores Before They Are Visible To Doctors
March, 17, 2015 | UCSF Surgical Innovations Program

Grants and Funding

  • Academic Training in Trauma and Burns | NIH | 1988-07-01 - 2013-06-30 | Role: Principal Investigator
  • HYPOXIA INDUCIBLE FACTOR-1. &DELAYED WOUND HEALING | NIH | 2004-09-01 - 2010-08-31 | Role: Principal Investigator
  • ROLE OF HEAT SHOCK PROTEINS IN CUTANEOUS BURN INJURY | NIH | 1999-09-30 - 2004-09-29 | Role: Principal Investigator
  • STUDY OF TRANSPLANTED ALLO-DERMIS &EPIDERMIS | NIH | 1990-12-31 - 1900-01-01 | Role: Principal Investigator

Research Narrative

Dr. Young is primarily interested in the mechanisms and treatments of normal and abnormal wound healing. He is Principal Investigator on a study pertaining to the role of heat shock proteins, homeobox genes, and hypoxia in cutaneous wound healing.

The effects of manipulating of hypoxia inducible proteins, homeobox genes, and heat shock proteins in wound repair are presently under investigation. In vitro and in vivo models of wound repair are used to study the effects of induction and blockage of these proteins on normal and abnormal healing. Expression of many of these proteins is altered in conditions of poor wound healing as found in patients with diabetes.

Dr. Young hopes to understand how these proteins interact during wound healing and to develop novel methods to improve healing. Dr. Young's research is conducted in the UCSF Surgical Research Laboratory at SFGH. The research is currently funded by a RO-1 grant "Diabetes, Hypoxia Inducible Factor-1, and Delayed Wound Healing" from the NIH-NIGMS.

Research Interests

  • Molecular mechanisms of wound healing
  • Epidemiology and treatment of soft tissue infections

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 30
  1. Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.
    Fazel Darbandi S, An JY, Lim K, Page NF, Liang L, Young DM, Ypsilanti AR, State MW, Nord AS, Sanders SJ, Rubenstein JLR| | PubMed
  2. A comprehensive AI model development framework for consistent Gleason grading.
    Huo X, Ong KH, Lau KW, Gole L, Young DM, Tan CL, Zhu X, Zhang C, Zhang Y, Li L, Han H, Lu H, Zhang J, Hou J, Zhao H, Gan H, Yin L, Wang X, Chen X, Lv H, Cao H, Yu X, Shi Y, Huang Z, Marini G, Xu J, Liu B, Chen B, Wang Q, Gui K, Shi W, Sun Y, Chen W, Cao D, Sanders SJ, Lee HK, Hue SS, Yu W, Tan SY| | PubMed
  3. Artificial intelligence-assisted quantification and assessment of whole slide images for pediatric kidney disease diagnosis.
    Feng C, Ong K, Young DM, Chen B, Li L, Huo X, Lu H, Gu W, Liu F, Tang H, Zhao M, Yang M, Zhu K, Huang L, Wang Q, Marini GPL, Gui K, Han H, Sanders SJ, Li L, Yu W, Mao J| | PubMed
  4. Automatic DNA replication tract measurement to assess replication and repair dynamics at the single-molecule level.
    Li L, Kolinjivadi AM, Ong KH, Young DM, Marini GPL, Chan SH, Chong ST, Chew EL, Lu H, Gole L, Yu W, Ngeow J| | PubMed
  5. Detection of subtle white matter lesions in MRI through texture feature extraction and boundary delineation using an embedded clustering strategy.
    Ong K, Young DM, Sulaiman S, Shamsuddin SM, Mohd Zain NR, Hashim H, Yuen K, Sanders SJ, Yu W, Hang S| | PubMed
  6. Preventing Recurrence in Clean and Contaminated Hernias Using Biologic Versus Synthetic Mesh in Ventral Hernia Repair: The PRICE Randomized Clinical Trial.
    Harris HW, Primus F, Young C, Carter JT, Lin M, Mukhtar RA, Yeh B, Allen IE, Freise C, Kim E, Sbitany H, Young DM, Hansen S| | PubMed
  7. Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain.
    Young DM, Fazel Darbandi S, Schwartz G, Bonzell Z, Yuruk D, Nojima M, Gole LC, Rubenstein JL, Yu W, Sanders SJ| | PubMed
  8. Satellite cell activation and retention of muscle regenerative potential after long-term denervation.
    Wong A, Garcia SM, Tamaki S, Striedinger K, Barruet E, Hansen SL, Young DM, Pomerantz JH| | PubMed
  9. Whole-Brain Image Analysis and Anatomical Atlas 3D Generation Using MagellanMapper.
    Young DM, Duhn C, Gilson M, Nojima M, Yuruk D, Kumar A, Yu W, Sanders SJ| | PubMed
  10. Contemporary concepts in hernia prevention: Selected proceedings from the 2017 International Symposium on Prevention of Incisional Hernias.
    Harris HW, Hope WH, Adrales G, Andersen DK, Deerenberg EB, Diener H, Dumanian G, East B, Fischer JP, Ureña MAG, Gibeily GJ, Hansson BM, Hernández-Granados P, Hiles MC, Jeekel J, Levinson H, Lopez-Cano M, Muysoms F, Pereira JA, Prudhomme M, Ramaswamy A, Stabilini C, Torkington J, Valverde S, Young DM| | PubMed
30
View all 30 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 30
  1. Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.
    Fazel Darbandi S, An JY, Lim K, Page NF, Liang L, Young DM, Ypsilanti AR, State MW, Nord AS, Sanders SJ, Rubenstein JLR| | PubMed
  2. A comprehensive AI model development framework for consistent Gleason grading.
    Huo X, Ong KH, Lau KW, Gole L, Young DM, Tan CL, Zhu X, Zhang C, Zhang Y, Li L, Han H, Lu H, Zhang J, Hou J, Zhao H, Gan H, Yin L, Wang X, Chen X, Lv H, Cao H, Yu X, Shi Y, Huang Z, Marini G, Xu J, Liu B, Chen B, Wang Q, Gui K, Shi W, Sun Y, Chen W, Cao D, Sanders SJ, Lee HK, Hue SS, Yu W, Tan SY| | PubMed
  3. Artificial intelligence-assisted quantification and assessment of whole slide images for pediatric kidney disease diagnosis.
    Feng C, Ong K, Young DM, Chen B, Li L, Huo X, Lu H, Gu W, Liu F, Tang H, Zhao M, Yang M, Zhu K, Huang L, Wang Q, Marini GPL, Gui K, Han H, Sanders SJ, Li L, Yu W, Mao J| | PubMed
  4. Automatic DNA replication tract measurement to assess replication and repair dynamics at the single-molecule level.
    Li L, Kolinjivadi AM, Ong KH, Young DM, Marini GPL, Chan SH, Chong ST, Chew EL, Lu H, Gole L, Yu W, Ngeow J| | PubMed
  5. Detection of subtle white matter lesions in MRI through texture feature extraction and boundary delineation using an embedded clustering strategy.
    Ong K, Young DM, Sulaiman S, Shamsuddin SM, Mohd Zain NR, Hashim H, Yuen K, Sanders SJ, Yu W, Hang S| | PubMed
  6. Preventing Recurrence in Clean and Contaminated Hernias Using Biologic Versus Synthetic Mesh in Ventral Hernia Repair: The PRICE Randomized Clinical Trial.
    Harris HW, Primus F, Young C, Carter JT, Lin M, Mukhtar RA, Yeh B, Allen IE, Freise C, Kim E, Sbitany H, Young DM, Hansen S| | PubMed
  7. Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain.
    Young DM, Fazel Darbandi S, Schwartz G, Bonzell Z, Yuruk D, Nojima M, Gole LC, Rubenstein JL, Yu W, Sanders SJ| | PubMed
  8. Satellite cell activation and retention of muscle regenerative potential after long-term denervation.
    Wong A, Garcia SM, Tamaki S, Striedinger K, Barruet E, Hansen SL, Young DM, Pomerantz JH| | PubMed
  9. Whole-Brain Image Analysis and Anatomical Atlas 3D Generation Using MagellanMapper.
    Young DM, Duhn C, Gilson M, Nojima M, Yuruk D, Kumar A, Yu W, Sanders SJ| | PubMed
  10. Contemporary concepts in hernia prevention: Selected proceedings from the 2017 International Symposium on Prevention of Incisional Hernias.
    Harris HW, Hope WH, Adrales G, Andersen DK, Deerenberg EB, Diener H, Dumanian G, East B, Fischer JP, Ureña MAG, Gibeily GJ, Hansson BM, Hernández-Granados P, Hiles MC, Jeekel J, Levinson H, Lopez-Cano M, Muysoms F, Pereira JA, Prudhomme M, Ramaswamy A, Stabilini C, Torkington J, Valverde S, Young DM| | PubMed
  11. Silver microparticles plus fibrin tissue sealant prevents incisional hernias in rats.
    Primus FE, Young DM, Grenert JP, Harris HW| | PubMed
  12. Biopolymer Molecular Weight Can Modulate the Wound Healing Efficacy of Multivalent Sonic Hedgehog-Hyaluronic Acid Conjugates.
    Holstlaw TA, Mahomed M, Brier LW, Young DM, Boudreau NJ, Jackson WM| | PubMed
  13. The effects of immunosuppressive medications on outcomes in microvascular free tissue transfer.
    Sbitany H, Xu X, Hansen SL, Young DM, Hoffman WY| | PubMed
  14. Klotho mice: a novel wound model of aged skin.
    Yamashita K, Yotsuyanagi T, Yamauchi M, Young DM| | PubMed
  15. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.
    Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY| | PubMed
  16. Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model.
    Restivo TE, Mace KA, Harken AH, Young DM| | PubMed
  17. Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism.
    Young DM, Schenk AK, Yang SB, Jan YN, Jan LY| | PubMed
  18. Open incisional hernia repair at an academic tertiary care medical center.
    Mohebali K, Young DM, Hansen SL, Shawo A, Freise CE, Chang DS, Maa J, Harris HW| | PubMed
  19. HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells.
    Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ| | PubMed
  20. Effects of decreased insulin-like growth factor-1 stimulation on hypoxia inducible factor 1-alpha protein synthesis and function during cutaneous repair in diabetic mice.
    Yu DH, Mace KA, Hansen SL, Boudreau N, Young DM| | PubMed
  21. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair.
    Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM| | PubMed
  22. Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice.
    Rajendran PM, Young DM, Maurer T, Chambers HF, Jacobson MA, Harris HW| | PubMed
  23. Inappropriate antibiotic use in soft tissue infections.
    Paydar KZ, Hansen SL, Charlebois ED, Harris HW, Young DM| | PubMed
  24. Hemangiomas and homeobox gene expression.
    Hansen SL, Dosanjh A, Young DM, Boudreau N, Hoffman WY| | PubMed
  25. HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair.
    Mace KA, Hansen SL, Myers C, Young DM, Boudreau N| | PubMed
  26. Photochemically knocking out glutamate receptors in vivo.
    Chambers JJ, Gouda H, Young DM, Kuntz ID, England PM| | PubMed
  27. An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients.
    Young DM, Harris HW, Charlebois ED, Chambers H, Campbell A, Perdreau-Remington F, Lee C, Mankani M, Mackersie R, Schecter WP| | PubMed
  28. HoxD3 accelerates wound healing in diabetic mice.
    Hansen SL, Myers CA, Charboneau A, Young DM, Boudreau N| | PubMed
  29. HoxD3 expression and collagen synthesis in diabetic fibroblasts.
    Hansen SL, Young DM, Boudreau NJ| | PubMed
  30. Care of injection drug users with soft tissue infections in San Francisco, California.
    Harris HW, Young DM| | PubMed