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Magnamosis

Magnetic compression anastomosis device

Principal Investigator: Michael R. Harrison, M.D.
Team Members: Dillon Kwiat, B.S., Jill Imamura-Ching, R.N., Veeshal Patel, M.D., M.B.A.

Challenge

 

2 million anastomosis procedures are performed annually worldwide, most commonly for anatomic reconstruction of disrupted intestine (due to cancer, trauma, bariatric surgery, inflammatory disease, congenital malformation, etc.).

Solution

 

Magnamosis is a novel surgical device and method for creating an anastomosis, or connection between two tubular structures in the body, such as loops of intestine. The device consists of two donut-shaped magnets that, when introduced into adjacent sections of bowel, create a compressive force to cause necrosis in the tissue between the magnets.  As the tissue between the magnets dies, the tissue around the magnets fuses to create a patent lumen between the two pieces of bowel. Designed to be safer, less invasive, easier to perform, and less expensive, Magnamosis offers many advantages over conventional sutures or surgical staplers and may be the enabling technology for new minimally invasive surgical procedures. 

magnamosis

Funding

 

National Institutes of Health SBIR

Publications

 

  • Pichakron KO, Jelin EB, Hirose S, Curran PF, Jamshidi R, Stephenson JT, Fechter R, Strange M, Harrison MR. Magnamosis II: Magnetic Compression Anastomosis for Minimally Invasive Gastrojejunostomy and Jejunojejunostomy. J Am Coll Surg. 2011 Jan;212(1):42-9.
  • Perretta S, Wall JK, Dallemagne B, Harrison M, Becmeur F, Marescaux J. Video: Two novel endoscopic esophageal lengthening and reconstruction techniques. Surg Endosc. 2011 Oct;25(10):3440.
  • Leroy JL, Perretta S, Diana M, Wall J, Lindner V, Harrison M, Marescaux J. An Original Endoluminal Magnetic Anastomotic Device Allowing Pure NOTES Transgastric and Transrectal Sigmoidectomy in a Porcine Model: Proof of Concept. Surg Innov. 2012 Jun;19(2):109-16.
  • Diana M, Wall J, Perretta S, Dallemagne B, Gonzales KD, Harrison MR, Agnus V, Soler L, Nicolau S, Marescaux J. Totally Endoscopic Magnetic Enteral Bypass by External Guided Rendez-Vous Technique. Surg Innov. 2011 Dec;18(4):317-20.
  • Hao Jiang, Shijie Chen, Kish S, Lokkee Loh, Junmin Zhang, Xiaorong Zhang, Kwiat D, Harrison M, Roy S. Miniaturizing RFID for magnamosis. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:638-641
  • Inductive sensing to detect tissue thickness between magnets for application in magnetic compression based anastomosis. Anupama Arun*1,2 PhD, Brandon Gaston1 BS, Dillon Kwiat1 BS, Jill Imamura-Ching1 RN, Richard Fechter1 BS, Shijie Chen3 BS, Hao Jiang3 PhD, Michael Harrison1, MD, FACS, Shuvo Roy2 PhD. Journal of Medical Devices. (accepted for publication on 12/22/2015)
  • Wall J, Diana M, Leroy J, Deruijter V, Gonzales KD, Lindner V, Harrison M, Marescaux J. MAGNAMOSIS IV: magnetic compression anastomosis for minimally invasive colorectal surgery. Endoscopy. 2013 Aug;45(8):643-8. 

Featured Media

 

We've seen the future of translational medicine and it's disruptive - UC Berkeley Blog - December 17, 2013

First-In-Human Pilot Trial for Magnetic Compression Anastomosis Device Reports Encouraging Results - UCSF Surgical Innovations - September 28, 2017

 
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